a Synuclein (Ab 136) Antibody Cat. No.: 79-604

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Mouse, Rat
IMMUNOGEN: a-Synuclein (Ab-136) antibody was raised against a peptide sequence around aa. 134~138 (Q-D-Y-E-P) derived from Mouse α-Synuclein.
TESTED APPLICATIONS: IF, WB
APPLICATIONS: Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
SPECIFICITY: This antibody detects endogenous level of total α-Synuclein protein.
PREDICTED MOLECULAR WEIGHT: 18 kDa

psi-iconProperties
PURIFICATION:Antibodies were purified by affinity-chromatography using epitope-specific peptide.
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Store antibody at -20˚C for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:Snca
ALTERNATE NAMES:NACP, alphaSYN, NACP, SYN, SYUA, alpha-synuclein
ACCESSION NO.:NP_001035916.1
PROTEIN GI NO.:109638747
GENE ID:20617
psi-iconBackground and References
BACKGROUND:May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
REFERENCES:1) Takahashi T, et al. J Biol Chem 2003 Oct 24; 278 (43): 42225-33Ahn BH, et al. J Biol Chem 2002 Apr 05; 277 (14): 12334-42Negro A, et al. FASEB J 2002 Feb; 16 (2): 210-2Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.

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