a catenin (phospho Ser641) Antibody Cat. No.: 79-503

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse
IMMUNOGEN: a-catenin (Phospho-Ser641) antibody was raised against a peptide sequence around phosphorylation site of serine 641 (D-D-S (p) -D-F) derived from Human α-catenin.
TESTED APPLICATIONS: WB
APPLICATIONS: Western Blot: 1:500~1:1000
SPECIFICITY: This antibody detects endogenous level of α-catenin only when phosphorylated at serine 641.
PREDICTED MOLECULAR WEIGHT: 100 kDa

psi-iconProperties
PURIFICATION:Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Store antibody at -20˚C for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:CTNNA1
ALTERNATE NAMES:CAP102, JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1, Cadherin-associated protein, Alpha E-catenin, NY-REN-13 antigen
ACCESSION NO.:NP_001894.2
PROTEIN GI NO.:55770844
GENE ID:1495
psi-iconBackground and References
BACKGROUND:Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role in cell differentiation.
REFERENCES:1) Hwang, S. G. et al. (2005) J. Biol. Chem. 280, 12758-12765Drees, F. et al. (2005) Cell 123, 903-915. Yamada, S. et al. (2005) Cell 123, 889-901. Kobielak, A. and Fuchs, E. (2004) Nat. Rev. Mol. Cell Biol. 5, 614-625.

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