Specifications
| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: |
Human, Mouse |
| IMMUNOGEN: |
a-catenin (Phospho-Ser641) antibody was raised against a peptide sequence around phosphorylation site of serine 641 (D-D-S (p) -D-F) derived from Human α-catenin. |
| TESTED APPLICATIONS: |
WB |
| APPLICATIONS: |
Western Blot: 1:500~1:1000 |
| SPECIFICITY: |
This antibody detects endogenous level of α-catenin only when phosphorylated at serine 641. |
| PREDICTED MOLECULAR WEIGHT: |
100 kDa |
Properties
| PURIFICATION: | Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| CLONALITY: | Polyclonal |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| CONCENTRATION: | 1 mg/mL |
| STORAGE CONDITIONS: | Store antibody at -20˚C for up to one year. |
Additional Info
| OFFICIAL SYMBOL: | CTNNA1 |
| ALTERNATE NAMES: | CAP102, JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1, Cadherin-associated protein, Alpha E-catenin, NY-REN-13 antigen |
| ACCESSION NO.: | NP_001894.2 |
| PROTEIN GI NO.: | 55770844 |
| GENE ID: | 1495 |
Background and References
| BACKGROUND: | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role in cell differentiation. |
| REFERENCES: | 1) Hwang, S. G. et al. (2005) J. Biol. Chem. 280, 12758-12765Drees, F. et al. (2005) Cell 123, 903-915. Yamada, S. et al. (2005) Cell 123, 889-901. Kobielak, A. and Fuchs, E. (2004) Nat. Rev. Mol. Cell Biol. 5, 614-625. |
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