5HT3E Antibody Cat. No.: 55-244

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human
IMMUNOGEN: This 5HT3E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-154 amino acids from the Central region of human 5HT3E.
TESTED APPLICATIONS: Flow, WB
APPLICATIONS: For WB starting dilution is: 1:1000

For FACS starting dilution is: 1:10~50
PREDICTED MOLECULAR WEIGHT: 51 kDa

psi-iconProperties
PURIFICATION:This antibody is purified through a protein A column, followed by peptide affinity purification.
CLONALITY:Polyclonal
ISOTYPE:Rabbit Ig
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:HTR3E
ALTERNATE NAMES:5-hydroxytryptamine receptor 3E, 5-HT3-E, 5-HT3E, Serotonin receptor 3E, HTR3E
ACCESSION NO.:A5X5Y0
GENE ID:285242
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The product of this gene belongs to the ligand-gated ion channel receptor superfamily. HTR3E encodes a subunit E of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. An alternative splice variant has been described but its full length sequence has not been determined.
REFERENCES:1) Walstab, J., et al. J. Biol. Chem. 285(35):26956-26965(2010)
2) Hammer, C., et al. Pharmacogenomics 11(7):943-950(2010)
3) Lennertz, L., et al. Eur Neuropsychopharmacol 20(6):414-420(2010)
4) Goecke, T.W., et al. Acta Obstet Gynecol Scand 89(1):7-14(2010)

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