| SPECIES: | Human |
| SOURCE SPECIES: | E. coli |
| SEQUENCE: | MERTRSLQDP CSNCPAGTFC DNNRNQICSP CPPNSFSSAG GQRTCDICRQ CKGVFRTRKE CSSTSNAECD CTPGFHCLGA GCSMCEQDCK QGQELTKKGC KNCCFGTFND QKRGICRPWT NCSLDGKSVL VNGTKERDVV CGPSPADLSP GASSVTPPAP AREPGHS |
| TESTED APPLICATIONS: | |
| BIOLOGICAL ACTIVITY: | Biological activity was determined by its inhibitory effect of the 4 - 1BBL mediated stimulation of IL - 8 production by human PBMC. About 90% of inibition was seen using a concentration of 1μg for both 4 - 1BBL and 4 - 1BBR. |
Specifications| PURITY: | Greater than 98% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg). |
| PHYSICAL STATE: | Lyophilized |
| STORAGE CONDITIONS: | The lyophilized 4-1BB Receptor recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted 4-1BB Receptor is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing 4-1BB Receptor recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. |
| ALTERNATE NAMES: | ILA, 4-1BB, CD137, CDw137, ILA, Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor |
| ACCESSION NO.: | NP_001552.2 |
| PROTEIN GI NO.: | 5730095 |
| OFFICIAL SYMBOL: | TNFRSF9 |
| GENE ID: | 3604 |
| BACKGROUND: | 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor. |
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