4-1BB Ligand / TNFSF9 Recombinant Protein Cat. No.: 11-387

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:HEK293 cells
SEQUENCE:Ala 50 - Glu 254
FUSION TAG:His Tag
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 23.3 kDa. The protein migrates as 25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:23.3 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS with Arginine, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:4-1BB Ligand,TNFSF9,CD137L
ACCESSION NO.:NP_003802.1
OFFICIAL SYMBOL:TNFSF9
GENE ID:8744
psi-iconBackground and References
BACKGROUND:Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.
REFERENCES:1) Won E.Y., et al., 2010, J. Biol. Chem. 285:9202-9210.
2) Alderson M.R., et al., 1994, Eur. J. Immunol. 24:2219-2227.

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