This recombinant protein can be used for E, WB. For research use only.
BIOLOGICAL ACTIVITY:
Measured by its binding ability in a functional ELISA. Immobilized Human 4-1BB, His Tag at 100 ng/mL (100 ul/well),can bind Human 4-1BB Ligand, Fc Tag with a linear of 0.1-2.5 ng/mL (Routinely tested).
Properties
PURITY:
>95% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
PREDICTED MOLECULAR WEIGHT:
47.4 kDa
PHYSICAL STATE:
Lyophilized
BUFFER:
Tris with Glycine, Arginine and NaCl, pH7.5
STORAGE CONDITIONS:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Additional Info
ALTERNATE NAMES:
#REF!
ACCESSION NO.:
NP_003802
OFFICIAL SYMBOL:
4‑1BB Ligand
GENE ID:
8744
Background and References
BACKGROUND:
Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.
REFERENCES:
1) Won E.Y., et al., 2010, J. Biol. Chem. 285:9202-9210.
2) Alderson M.R., et al., 1994, Eur. J. Immunol. 24:2219-2227.
Specifications
