2019-nCoV Nucleocapsid Recombinant Protein Cat. No.: 97-085

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psi-iconSpecifications
SPECIES:SARS-CoV-2
SOURCE SPECIES:HEK293 cells
SEQUENCE:Met 1 - Ala 419
FUSION TAG:His Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:49.4 kDa
PHYSICAL STATE:Lyophilized
BUFFER:Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
STORAGE CONDITIONS:Lyophilized protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:Nucleocapsid protein, NP, Protein N
ACCESSION NO.:QHO62115.1
psi-iconBackground and References
BACKGROUND:Nucleocapsid protein is a most abundant protein of coronavirus. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. While screening for ADP-ribosylated proteins during coronavirus (CoV) infection, we identified as the viral nucleocapsid (N) protein. Novel post-translation modification of the CoV N protein that may play a regulatory role for this important structural protein. The array of diverse functional activities accommodated in the hantaviral N protein goes far beyond to be a static structural protein and makes it an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.
REFERENCES:1) Reuter M, et al. Virus Genes. 2018. 54(1):5-16.
2) Grunewald ME, et al. Virology. 2018. 517:62-68.
3) Jeeva S, et al. PLoS One. 2017. 12(9):e0184935.

FOR RESEARCH USE ONLY.

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