14 3 3 zeta (phospho Ser58) Antibody Cat. No.: 79-188

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: 14-3-3 zeta (Phospho-Ser58) antibody was raised against a peptide sequence around phosphorylation site of serine 58 (R-S-S (p) -W-R) derived from Human 14-3-3 zeta.
TESTED APPLICATIONS: IF, IHC, WB
APPLICATIONS: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
SPECIFICITY: This antibody detects endogenous level of 14-3-3 zeta only when phosphorylated at serine 58.
PREDICTED MOLECULAR WEIGHT: 28 kDa

psi-iconProperties
PURIFICATION:Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Store antibody at -20˚C for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:YWHAZ
ALTERNATE NAMES:HEL4, YWHAD, KCIP-1, HEL-S-3, 14-3-3-zeta, JNK2, PRKM9, SAPK1A, 1433Z, 143Z, FAS, Factor activating exoenzyme S
ACCESSION NO.:NP_001129171.1
PROTEIN GI NO.:208973238
GENE ID:7534
psi-iconBackground and References
BACKGROUND:This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.
REFERENCES:1) Gu YM, et al. (2006) FEBS Lett ; 580 (1): 305-310Powell DW, et al. (2003) Mol Cell Biol; 23 (15): 5376-5387Mackintosh C. (2004) Biochem J; 381 (Pt 2): 329-342.

ANTIBODIES FOR RESEARCH USE ONLY.

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