14-3-3 sigma Antibody Cat. No.: 33-020

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: A recombinant protein fragment from the internal region of 14-3-3 sigma was used as the immunogen for this antibody. The amino acid sequence is common to the ~30kDa and ~20kDa isoforms.
TESTED APPLICATIONS: WB
APPLICATIONS: Western blot: 1-3 ug/ml

Provided assay concentrations are suggestions only, 14-3-3 sigma antibody titration may be required for optimal results.

psi-iconProperties
PURIFICATION:Protein A affinity chromatography
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:PBS with 0.1 mg/ml BSA and 0.05% sodium azide
CONCENTRATION:0.5 mg/mL
STORAGE CONDITIONS:Aliquot and Store at -20˚C. Avoid freez-thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:SFN
ALTERNATE NAMES:14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1
GENE ID:2810
USER NOTE:Optimal dilutions for each application to be determined by the researcher
psi-iconBackground and References
BACKGROUND:14-3-3 proteins are regulators of a diverse group of signaling proteins, including kinases, phosphatases, and transmembrane receptors, and have roles in a wide range of physiological processes including transcription, intracellular signaling, cell cycle control and apoptosis. There are seven 14-3-3 proteins in most mammals: beta, gamma epsilon, zeta, eta, sigma and tau. 14-3-3 sigma, also called Stratifin, is a product of the SFN gene. It is a tumor suppressor gene inactivated via DNA methylation. Reduced or no expression of 14-3-3 sigma is seen in various carcinoma including skin, breast and prostate, suggesting that 14-3-3 gene silencing may be involved in tumor progression.

ANTIBODIES FOR RESEARCH USE ONLY.

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