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High Performance Antibodies...and More

COVID-19

SARS-CoV-2 Variants

Spike antibodies and recombinant proteins representing key mutations such as P681H, N501Y, K417N, K417T, and E484K.

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SARS-CoV-2 Antibody Pairs

Capture and detection antibodies against SARS-CoV-2 nucleocapsid and spike proteins.

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SARS-CoV-2 Antibodies Validated with Patient Samples

Antibodies against structural and nonstructural proteins validated with the SARS-CoV-2 virus.

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ACE-2 Antibodies

ACE2, TMPRSS2, and Furin antibodies and recombinant proteins.

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SARS CoV Small Molecule Inhibitors

Small molecule inhibitors for viral entry, proteases, RdRps … and more.

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SARS-CoV-2 Accessory Factors Reagents

Variant and wild type proteins to spike, envelope, membrane, nucleocapsid, ORFs, ACE2 … and more.

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Viral Infectious Diseases Research Reagents

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SARS-CoV-2 Research Reagents

ProSci enables advancements in COVID-19 research with its broad catalog of antibodies, proteins … and more.

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Immune Checkpoint

VISTA

VISTA is an immunoregulatory receptor that inhibits the T-cell response. May promote embryonic stem cell differentiation.

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TMIGD2

TMIGD2 plays a role in cell migration, cell-cell interation, and angiogenesis. Enhances cytokine production and T-cell proliferation.

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TIM-3

TIM3 (HAVCR2) is a specific T helper type 1 (Th1) cell surface marker. Promotes immune tolerance.

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TIGIT

TIGIT binding to PVR causes increased secretion of IL-10 and decreased secretion of IL-12B. Suppresses T-cell activation.

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PD-L2

PD-L2 inhibits T-cell proliferation by blocking cell cycle and cytokine production upon binding to PD-1.

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PD-L1

PD-L1 (CD274) is a strong immunosuppressor, inhibiting cytokine production and T-cell activation upon binding to PD-1.

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PD-1

PD-1 receptor induces and maintains immune tolerance to self. May play a role in pro-B-cell differentiation.

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LIGHT

LIGHT (TNFSF14) is a cytokine which stimulates T-cell proliferation and IFNG production.

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LAG-3

LAG3 of the immunoglobulin superfamily mediates immune tolerance, delivering inhibitory signals upon ligand binding.

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CTLA-4

CTLA4 (CD152) of the immunoglobulin superfamily inhibits T-cells; soluble monomer or membrane homodimer.

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CD80

When activated by CD28 or CTLA-4, CD80 induces T-cell proliferation and cytokine production.

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B7-H3

B7-H3 (CD276) is only expressed in tumors; thought to aid regulation of T-cell-mediated immune response.

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Immune Checkpoint Research Reagents

High performance mouse monoclonal and llama single domain recombinant antibodies to top immune checkpoint targets.

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Explore Our New Products

ProSci is continuously enabling researchers worldwide through the development of high performance antibodies … and more.

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  • Infectious Disease Reagents

    A leader in viral infectious disease research reagents, ProSci is continuously expanding its infectious disease research reagent portfolio. View the ProSci Comprehensive Viral Research Reagents catalog. Learn more
  • Influenza Research Reagents

    ProSci was the first to develop antibodies to newly emerged influenza strains of avian and swine origin. Browse H5N1 and H7N9 avian and seasonal flu, H1N1 swine and season flu, H3N2, and influenza A and B reagents.

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Stay up to date

Latest News

Blog

What is a Pseudovirus?...

June 23, 2022

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Blog, News, Research Highlights

Highly Contagious Influenza Virus...

June 15, 2022

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Blog

Monkeypox Virus: A breakthrough in Scientific News...

June 14, 2022

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ProSci Instagram Feed

The #monkeypox virus that has been reported in mai The #monkeypox virus that has been reported in mainstream and scientific news is part of the Orthopoxvirus genus that closely resembles the #smallpox (variola) virus. 

The genetic code of monkeypox is similar enough to smallpox that known vaccines, such as those developed against the #VacciniaVirus, as well as anti-viral treatments are found to be effective in dampening its spread and adverse physiological effects. 

As reported by Nature on May 28th,  the impact on human health is concerning but it is the unusual spread of the disease that is perking curiosity amongst researchers. 

For decades this virus had been contained to animal populations with some spread to humans in Central and Eastern Africa. It has been recently identified to be spreading in humans and in countries around the world where the virus was not previously identified. 

Epidemiologists are working diligently to determine the causes of the abnormal distribution of the virus. 

🔗 Read more on our blog! Link in bio.
The #monkeypox virus that has been reported in mai The #monkeypox virus that has been reported in mainstream and scientific news is part of the Orthopoxvirus genus that closely resembles the #smallpox (variola) virus. ProSci supports infectious disease researchers with several tools to help advance discoveries and breakthroughs. 

Have a question about our research tools? Contact our antibody experts today! Link in bio.
Two Featured #Antibodies of the Week! ProSci #CXCR Two Featured #Antibodies of the Week! ProSci #CXCR4 Antibody and #TAB1 Antibody.

Learn how ProSci Incorporated #CXCR4 Antibody – Cat. No. 1009 – was used in this study published in #BiomedicineandPharmacotherapy, where researchers demonstrate how the multivalent T22-DITOX-H6 nanoparticle, with its active targeting to CXCR4-overexpressing lymphoma cells and the potent mechanism of action of diphtheria toxin shows promise for an effective and safe strategy to eliminate CXCR4+ DLBCL cells. https://doi.org/10.1016/j.biopha.2022.112940

Image 1: #Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-CXCR4 antibody (1009) at 5 μg/ml. 

Image 2: #KOValidation of CXCR4 by #FlowCytometry (Ödemis, et al., 2010). 

Learn how ProSci Incorporated #TAB1 Antibody – Cat. No. 3387 – was used in this study conducted by Daoud, et. al., Researchers revealed that XIAP ubiquitylates #RIPK2, involve TAB1/RIPK2 complex, and induce the transcriptional up-regulation and secretion of chemokines such as #IL8, that are responsible for intra-tumour neutrophil accumulation. https://doi.org/10.15252/embr.202153608

Image 3: #Immunocytochemistry of TAB1 in K562 cells with TAB1 antibody at 1 μg/mL.

Thank you University of Cologne Department of Immunology for trusting ProSci #antibodies in your research!
🧪 Happy Friday from your #AntibodyExperts at Pr 🧪 Happy Friday from your #AntibodyExperts at ProSci!

#TGIF

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