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Primary Antibodies
YWHAE Antibody
Background
FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
SUBUNIT: Homodimer. Interacts with NDEL1 (By similarity). Interacts with HCV core protein.
SUMMARY: This protein product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer.
Additional Names
1433 protein epsilon, 14-3-3E
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Description
Left: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
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Location
The gene that codes for this protein is at chromosomal location 17p13.3.
Purification
Immunoaffinity Purified
Clonality / Clone
This is a polyclonal antibody.
Host
YWHAE antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
1-255
Application
14-3-3 protein epsilon antibody can be used for the detection of 14-3-3 protein epsilon by Western Blot.
Tested Application
WB
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
YWHAE antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H, M, R, B
Protein GI Number
5803225
Protein Accession Number
NP_006752.1
Molecular Weight
29.2 kDa (calculated)
Short Description
14-3-3 protein epsilon, 14-3-3E
This product belongs to the following categories:
Related Products
Datasheet 0801-W
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