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Primary Antibodies
UCHL1 Antibody
Background
FUNCTION: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
DISEASE: Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. In AD, UCHL1 was found to be associated with neurofibrillary tangles.
Additional Names
Ubiquitin carboxylterminal hydrolase isozyme L1, UCH-L1, Ubiquitin thiolesterase L1, Neuron cytoplasmic
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Description
Left: E coli-derived fusion protein as test antigen. Affi-pure IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. N: Pre-immune IgY, A: affi-pure IgY.
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Location
The gene that codes for this protein is at chromosomal location 4p14.
Purification
Immunoaffinity Purified
Clonality / Clone
This is a polyclonal antibody.
Host
UCHL1 antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
103-160
Application
Ubiquitin carboxyl-terminal hydrolase isozyme L1 antibody can be used for the detection of Ubiquitin carboxyl-terminal hydrolase isozyme L1 by Western Blot.
Tested Application
WB
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
UCHL1 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H
Protein GI Number
21361091
Protein Accession Number
NP_004172.2
Molecular Weight
24.8 kDa (calculated)
Short Description
Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1
This product belongs to the following categories:
Datasheet 0801-W
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