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Primary Antibodies
Transthyretin Antibody
Background
Transthyretin is a tetrameric carrier protein that transports thyroid hormones in the plasma and cerebrospinal fluid, and retinol (vitamin A) in the plasma. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. The diseases caused by mutations include familial amyloidotic polyneuropathy, euthyroid hyperthyroxinemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome. It has also been suggested that Transthyretin plays an important role in the maintenance of normal cognitive processes during aging, neuropeptide processing and nerve regeneration. It has also been linked to several pathological conditions including Parkinson’s disease, schizophrenia, and depression.
Additional Names
Transthyretin,TTR, PALB, TBPA, HsT2651
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Description
Left: Western blot analysis of Transthyretin in human lung tissue lysate with Transthyretin antibody at (A) 1 and (B) 2 μg/ml.
Below: Immunohistochemistry of Transthyretin in human lung tissue with Transthyretin antibody at 2.5 μg/ml.
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Other Product Images
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Source
Transthyretin antibody was raised against a 17 amino acid peptide near the center of human Transthyretin .
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
Transthyretin antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Application
Transthyretin antibody can be used for detection of Transthyretin by Western blot at 1 – 2 μg/ml.
Tested Application
E, WB, IHC
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat.No. 5157P - Transthyretin Peptide
Storage
Transthyretin antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1302 - Human Lung Tissue Lysate
Species Reactivity
H, M, R
Protein GI Number
136464
Protein Accession Number
P02766
Short Description
a tetrameric carrier protein
This product belongs to the following categories:
References- Fleming CE, Nunes AF, and Sousa MM. Transthyretin: more than meets the eye. Prog. Neurobiol. 2009; epub.
- Fleming CE, Saraiva MJ, and Sousa MM. Transthyretin enhances nerve regeneration. J. Neurochem. 2007; 103:831-9.
- Rite I, Arguelles S, Venero JL, et al. Proteomic identification of biomarkers in the cerebrospinal fluid in a rat model of nigrostriatal dopaminergic degeneration. J. Neurosci. Res. 2007; 85:3607-18.
Datasheet 09-01W
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