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| Ar | Arabidopsis |
| B | Bovine |
| BA | Baboon |
| Bc | Bacteria |
| Bl | Blocking |
| Bt | Biotinylated |
| Ce | C. elegans |
| C | Chicken |
| Chm | Chimpanzee |
| CP | Carp |
| CT | C-Terminus |
| D | Dog |
| Ds | Drosophila |
| E | ELISA |
| ED | Extracellular Domain |
| EL | Extracellular Loop |
| F | Feline |
| FACS | Flow Cytometry |
| Fu | Fungus |
| G | Guinea Pig |
| Gt | Goat |
| H | Human |
| HM | Hamster |
| Hr | Horse |
| I | Immunogen |
| ICC | Immunocytochemistry |
| ID | Intracellular Domain |
| IF | Immunofluorescence |
| IHC | Immunohistochemistry |
| IN | Intermediate Domain |
| IP | Immunoprecipitation |
| M | Mouse |
| Ma | Mammal |
| Mk | Monkey |
| MS | Mass Spectrometry |
| Mt | M. tuberculosis |
| N | Neutralization |
| NT | N-Terminus |
| P | Porcine |
| Pa | Parasite |
| PF | Puffer Fish |
| Pl | Plant |
| Pz | Protozoan |
| R | Rat |
| Rb | Rabbit |
| S | Sheep |
| V | Virus |
| WB | Western Blot |
| X | Xenopus |
| Y | Yeast |
| ZF | Zebra Fish |
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Products
Primary Antibodies
Toll-like Receptor (TLR) Related Antibodies
Toll-like receptors (TLR) are a family of proteins which are pattern recognition receptors (PRR) because they recognize microbial structures which have been conserved over evolution called pathogen-associated molecular patterns (PAMPs). Toll-like receptors (TLR) play an important role in both adaptive and innate immunity. Toll-like receptors are present on many different cell types including macrophages, dendritic cells, endothelium cells, mast cells, eosinophils, neutrophils, B lymphocytes, epithelial cells, cardiac myocytes and adipocytes. Additionally, Toll-like receptors (TLR) can activate antigen presenting cells (APC) causing them to release pro-inflamitory cytokines, chemokines, and nitric oxide which results in increased expression of co-stimulatory molecules. This change in the antigen presenting cells allows induction of the adaptive immune response via the toll-like receptor (TLR) signaling pathway. Individual toll-like receptors interact with different combinations of adaptor proteins, and activate various transcription factors and kinases. This constitutes the toll-like receptor (TLR) signaling pathway.
MyD88 is an important adaptor protein, and an integral part of the toll-like receptor (TLR) signaling pathway. MyD88 links members of the toll-like receptor (TLR) family and the interleukin-1 receptor (IL-1R) family to downstream activation of NF-κB and mitogen activated protein kinases. Another important toll-like receptor (TLR) signaling group is a family of proteins called the interleukin-1 receptor associated kinase (IRAK) which is made up of IRAK, IRAK-2, IRAK-4, and IRAK-M. Interleukin-1 receptor associated kinase (IRAK) is responsible for mediating signaling between MyD88 and tumor necrosis factor receptor associated factor 6 (TRAF6). Therefore much of the toll-like receptor (TLR) pathway goes through interleukin-1 receptor associated kinase (IRAK) proteins. Each interleukin-1 receptor associated kinase (IRAK) member has a unique regulatory role in mediating immune responses, and IRAK-4 is required for innate immunity.
ProSci has many toll-like receptor related antibodies, including antibodies to the proteins mentioned here. ProSci’s toll-like receptor related antibodies include antibodies against all 10 toll-like receptors, toll-like receptor 1-10 (TLR1-10), MyD88, IRAK, IRAK-2, IRAK-4 and IRAK-M. Additionally, we offer an IRAK Detection Set, a TLR Detection Set, and a TLR Adaptor Detection Set. ProSci antibodies and detection sets are appropriate for ELISA, western blot, and immunohistochemistry (IHC) applications as noted for each toll-like receptor related antibody or related detection set.
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| BAP29 Antibody |
3667 |
H, M, R |
E, WB, IHC |
(IN) A novel B-cell receptor-associated protein family member |
| BAP31 Antibody |
3665 |
H, M, R |
E, WB, IHC |
A novel B-cell receptor-associated protein family member |
| BH3-Only Protein Detection Set |
PSI-1816 |
see datasheet |
WB, IHC |
Bad, Bid, Bik, Bim, Bmf, Hrk, Noxa and PUMA |
| Bif Antibody |
3817 |
H, M |
E, WB, ICC |
a member of the Bcl-2 family |
| Bik Antibody |
3819 |
H, M |
E, WB, ICC |
a member of the Bcl-2 family |
| BTK Antibody |
3395 |
H, M |
E, WB, ICC |
(NT) Bruton's Tyrosine Kinase |
| CD31 Monoclonal Antibody |
32-131 |
H |
E, WB, IHC |
Platelet endothelial cell adhesion molecule 1 |
| Clusterin Antibody |
3856 |
H |
E, WB, IHC |
Apolipoprotein J |
| ECSIT Antibody |
3377 |
H, M |
E, WB, IHC |
(CT) An intermediate in the TLR and Bmp signaling pathways |
| HBUCE1 Antibody |
XW-8020 |
H |
WB |
Ubiquitin-conjugating enzyme 1 isoform, |
| IRAK Antibody |
1007 |
H, M, R |
E, WB, ICC, IP |
(CT) IL-1R associated kinase |
| IRAK Detection Set |
PSI-1802 |
see datasheet |
WB, IHC |
IRAK, IRAK-2, IRAK-M, IRAK-4 and MyD88 |
| IRAK Monoclonal Antibody |
PM-5315 |
H, M |
E, WB, IHC |
IL-1-Receptor Associated Kinase |
| IRAK Monoclonal Antibody |
PM-5317 |
H, M |
E, WB, IHC |
IL-1-Receptor Associated Kinase |
| IRAK-2 Antibody |
2213 |
H |
E, WB, IF |
(CT) IL-1R Associated Kinase |
| IRAK-4 Antibody |
3125 |
H |
E, WB, ICC |
A member in IRAK/Pelle family |
| IRAK2 Antibody |
3595 |
H, M |
E, WB, ICC |
(CT) mouse IL-1R associated kinase |
| IRAK2 Antibody |
3597 |
M |
E, WB |
(C2) mouse IL-1R associated kinase |
| IRE1p Antibody |
3657 |
H, M, R |
E, WB, ICC |
(NT) Endoplasmic reticulum-to-nucleus signaling 1 |
| IRE1p Antibody |
3659 |
H |
E, WB |
(IN) Endoplasmic reticulum-to-nucleus signaling 1 |
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