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Primary Antibodies
TMEM38B Antibody
Background
TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
Additional Names
TMEM38B, Transmembrane protein 38B, TRIC-B, TRICB, trimeric cation channel type B
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Description
Left: Western blot analysis of TMEM38B in rat thymus tissue lysate with TMEM38B antibody at (A) 1 and (B) 2 μg/ml.
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Source
TMEM38B antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human TMEM38B.
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
TMEM38B antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application
TMEM38B antibody can be used for detection of TMEM38B by Western blot at 1 - 2 μg/ml.
Tested Application
E, WB
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat.No. 5523P - TMEM38B Peptide
Storage
TMEM38B antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1471 - Rat Thymus Tissue Lysate
Species Reactivity
H, M, R
Protein GI Number
8922461
Protein Accession Number
NP_060582
Short Description
Transmembrane protein 38B
This product belongs to the following categories:
References- Yazawa M, Ferrante C, Feng J, et al. TRIC channels are essential for Ca2+ handling in intracellular stores. Nature 2007; 448:78-82.
- Yamakazi D, Yamakazi T, and Takeshima H. New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiocytes. Pharmacol. Ther. 2009; 121:265-72.
- Yamakazi D, Yamakazi T, and Takeshima H. New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiocytes. Pharmacol. Ther. 2009; 121:265-72.
Datasheet 10-01W
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