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Primary Antibodies
TLR10 Antibody
Background
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (4,5). TLR10 is highly homologous to TLRs 1 and 6 and is most highly expressed in lymphoid tissues (6). Most recently genetic variation in TLR10 has been associated with contributing to asthma risk (7). It should be noted that TLR10 exists in mice only as a pseudogene (8).
Additional Names
TLR10 (IN), TLR10, CD290
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Description
Left: Western blot analysis of TLR10 in human lymph node cell lysates with TLR10 antibody (IN) at (A) 0.5 and (B) 1 μg/ml.
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Source
TLR10 antibody was raised against a peptide corresponding to 14 amino acids near the middle of human TLR10.
Purification
Ion exchange chromatography purified
Clonality / Clone
This is a polyclonal antibody.
Host
TLR10 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
Human TLR10 (Intermediate Domain) Peptide (Cat. No. 3275P)
Application
TLR10 antibody can be used for detection of TLR10 by Western blot at 0.5 to 1 μg/ml. Despite its predicted size of ~90 kDa, a band correpsonding to TLR10 is observed at ~75 kDa in immunoblot assays.
Tested Application
E, WB
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat. No. 3275P - TLR10 Peptide
Storage
TLR10 antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1369 - Human Lymph node Tissue Lysate
Species Reactivity
H
Protein GI Number
37181720
Protein Accession Number
AAQ88667
Short Description
(IN) Toll-like receptor protein
This product belongs to the following categories:
Related Products
References- Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.
- Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
- Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
- O’Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.
Datasheet 08-02W
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