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Primary Antibodies
TIM-1 Antibody
Background
The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.
Additional Names
TIM-1 (IN), T cell immunoglobulin and mucin domain containing protein 1, Hepatitis A virus cellular receptor 1, HAVcr-1, Kim-1
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Description
Left: Western blot analysis of TIM-1 in human uterus tissue lysate with TIM-1 antibody at (A) 1 and (B) 2 μg/ml.
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Source
TIM-1 antibody was raised against a 16 amino acid peptide from near the center of human TIM-1.
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
TIM-1 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application
TIM-1 antibody can be used for the detection of TIM-1 by Western blot at 1 – 2 μg/ml.
Tested Application
E, WB
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat.No. 3811P - TIM-1 Peptide
Storage
TIM-1 antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1317 - Human Uterus Tissue Lysate
Species Reactivity
H, M, R
Protein GI Number
153085427
Protein Accession Number
NP_036338
Short Description
(IN) T cell immunoglobulin and mucin domain containing protein 1
This product belongs to the following categories:
Related Products
References- Feigelstock D, Thompson P, Mattoo P, et al. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J. Virol. 1998; 72:6621-8.
- Ichimura T, Bonventre JV, Bailly V, et al. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J. Biol. Chem. 1998; 273:4135-42.
- Meyers JH, Sabatos CA, Chakravarti S, et al. The TIM family regulates autoimmune and allergic diseases. Trends Mol. Med. 2005; 11:362-9.
- Meyers JH, Chakravarti S, Schlesinger D, et al. TIM-4 is the ligand for TIM-1, and the TIM-1-TIM4 interaction regulates T cell proliferation. Nat. Immunol. 2005; 6:455-64.
Datasheet 08-02W
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