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Primary Antibodies
TACI Antibody
Background
Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 (1-4) and April/TALL-2, respectively, (3,5). BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion (1,2). April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified (6,7). TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-κB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
Additional Names
TACI
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Description
Left: Western blot analysis of TACI in K562 (A) and U937 (B) cell lysates with TACI antibody at 5 μg/ml.
Below: Immunocytochemistry of TACI in K562 cells with TACI antibody at 2 μg/ml.
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Other Product Images
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Source
TACI antibody was raised against a synthetic peptide mapping at the amino terminus of human TACI .
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
TACI antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
Human TACI Peptide (Cat. No. 2395P)
Application
TACI polyclonal antibody can be used for detection of TACI by Western blot at 2 to 5 μg/ml.
Tested Application
E, WB, ICC
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat. No. 2395P - TACI Peptide
Storage
TACI antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1204 - K562 Cell Lysate
- Cat. No. 1215 - U937 Whole Cell Lysate
Species Reactivity
H
Protein GI Number
6912694
Protein Accession Number
NP_036584
Short Description
Receptor for BAFF and APRIL
This product belongs to the following categories:
Related Products
References- Moore PA, Belvedere O, Orr A, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999;285:260-3
- Schneider P, MacKay F, Steiner V, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999;189:1747-56
- Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol 1999;65:680-3
- Mukhopadhyay A, Ni J, Zhai Y, Yu GL, Aggarwal BB. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-κB, and c-Jun NH2-terminal kinase. J Biol Chem 1999 ;274:15978-81
Datasheet 08-02W
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