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Primary Antibodies
Slit Homolog 1 Antibody
Background
SLIT-1 (also known as KIAA0813, MEGF4, multiple epidermal growth factor-like domains 4 and Slit homolog 1 protein) is a Slit protein. This protein is a ligand for the Roundabout (Robo) receptors and acts as guidance cues in axonal migration/navigation during neural development, at the ventral midline of the neural tube. Slit1 and Slit2 are essential for midline guidance in the forebrain by acting as repulsive signals preventing inappropriate midline crossing by axons projecting from the olfactory bulb. Each SLIT gene encodes a putative secreted protein, which contains conserved protein-protein interaction domains including leucine-rich repeats and epidermal growth factor-like motifs, similar to those of the Drosophila protein. In situ hybridization studies indicated that the rat SLIT-1 mRNA was specifically expressed in the neurons of fetal and adult forebrains. This data suggests that the SLIT genes form an evolutionarily conserved group in vertebrates and invertebrates, and that the mammalian SLIT proteins may participate in the formation and maintenance of the nervous and endocrine systems by protein-protein interactions. Alternative splicing isoforms have been identified for Slit1 protein.
Additional Names
SLIT1, KIAA0813, MEGF4, SLIL1, SLIT-1, SLIT3
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Description
Left: Immunohistochemistry staining of Slit Homolog 1 in brain, cortex (formalin-fixed paraffin-embedded) using Slit Homolog 1 antibody.
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Purification
Immunoaffinity Chromatography
Clonality / Clone
This is a polyclonal antibody.
Host
Slit Homolog 1 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
Slit Homolog 1 antibody was raised against aa 487-504 of Slit Homolog 1. (Mouse)
Application
Slit Homolog 1 antibody can be used for detection of Slit Homolog 1 by WB (1:500 - 1:2000), ELISA (1:10000 - 1:50000), IF, IHC-parafin (5 μg/ml).
Tested Application
E, WB, IHC, IF
Buffer
Slit Homolog 1 antibody is supplied in 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
Storage
Slit Homolog 1 antibody can be stored at 4˚C or -20˚C, Avoid repeated freezing and thawing.
Species Reactivity
H, C, X
Formulation
Weight: 50 μg
Concentration: 1 mg/ml
Short Description
Slit Homolog 1
This product belongs to the following categories:
Datasheet 09-01W
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