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Primary Antibodies
SNCA Monoclonal Antibody
Background
Alpha-synuclein (SNCA), with 140-amino acid protein (about 15kDa), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.
Additional Names
PD1, NACP, PARK1, PARK4, MGC110988
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Description
Left: Western blot analysis using SNCA monoclonal antibody against truncated SNCA recombinant protein.
Below: Immunohistochemical analysis of paraffin - embedded human glioma tissue showing membrane location using SNCA antibody with DAB staining.
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Other Product Images
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Clonality / Clone
This is a monoclonal antibody. Clone 2B2D1, 2B2A11.
Host
SNCA monoclonal antibody was raised in mouse.
Please use anti-mouse secondary antibodies.
Immunogen
Ni-NTA purified truncated recombinant SNCA expressed in E. Coli strain BL21 (DE3).
Application
Western Blot:1:500 - 1:2,000
IHC(P):1:500 - 1:2,000
IHC(F):1:500 - 1:2,000
ELISA:Propose dilution 1:10,000
Determining optimal working dilutions by titration test.
Tested Application
E, WB, IHC
Storage
SNCA monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H
Formulation
Ascitic fluid containing 0.03% sodium azide.
Purified antibody available at no extra cost.
Protein GI Number
6622
Short Description
Belongs to the synuclein family
This product belongs to the following categories:
References- J. Johnson, S. M. Hague, M. Hanson. Neurology, Aug 2004; 63: 554 – 556.
- Hong Tao Li, Xiao Jing Lin, Yuan Yuan Xie. Protein Pept Lett. 2006;13(4):385-90.
Datasheet 0903-W
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