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Primary Antibodies
SMAD2 Antibody
Background
SMAD2 is an intracellular protein belonging to the Dwarfin (DWA/B)/SMAD family. SMAD2 associates with SMAD4 for translocation to nucleus. It acts as an intracellular mediator of TGFbeta family of cytokines and activin type 1 receptor (ACVR1C). Hence it regulates multiple cellular processes like cell growth, proliferation, differentiation, and apoptosis and also cooperates with transcription factors to regulate expression of defined genes. Apart from playing an important role in TGFbeta1-induced CTGF expression they also act as markers of EMT in human PTECs. It also acts as an integrator of multiple signals in the regulation of NOS3 expression. It is ubiquitously expressed in most of the tissues and is responsible for colorectal, hepatocellular, lung and breast carcinomas as well as cervical cancer.
Additional Names
SMAD2, HMAD-2, HSMAD2, JV18, JV18-1, MADH2, MADR2, MGC22139, MGC34440, mad protein homolog smad2
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Description
Left: Immunohistochemistry staining of SMAD2 in placenta (formalin-fixed paraffin-embedded) using SMAD2 antibody.
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Purification
Protein G Column
Clonality / Clone
This is a polyclonal antibody.
Host
SMAD2 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
SMAD2 antibody was raised against amino acids 234-249 of SMAD2. (Human)
Application
SMAD2 antibody can be used for detection of SMAD2 by WB (2 - 4 μg/ml), IHC-parafin (5 μg/ml).
Tested Application
WB, IHC
Buffer
SMAD2 antibody is supplied in PBS, 0.05% BSA, 0.05% sodium azide.
Storage
SMAD2 antibody can be stored at 4˚C for short term storage, for long term storage aliquot and store at -20˚C . Avoid freeze thaw cycles.
Species Reactivity
M, R, B, C, D, Chm
Formulation
Weight: 50 μg
Concentration: 0.5 mg/ml
Short Description
SMAD
This product belongs to the following categories:
Datasheet 09-01W
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