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Primary Antibodies
SERPINA1 Antibody
Background
Chicken polyclonal IgY Antibodies against α-1 antitrypsin (SERPINA 7), antigen affintiy-purified. A single polypeptide chain of 394 amino acids and three carbohydrate side chains linked to asparaging residues. This is a serine protease inhibitor that also acts as a major physiological regulator of elastase. Deficiency of this protein is associated with emphysema and liver disease. M.W. 52,000.
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Description
Direct ELISA: Recombinant protein as test antigen. Affinity-purified IgY as primary antibody (0.1 μg/ml), and Rabbit anti-IgY-HRP as 2nd antibody.
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Location
The gene that codes for this protein is at chromosomal location 14q32.1.
Purification
Antigen affinity-purified
Clonality / Clone
This is a polyclonal antibody.
Host
SERPINA1 antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
Full Length
Application
SERPINA1 antibody can be used for the detection of a-1-Antitrypsin by Western blot, ELISA, IP, may also work for IHC and ICC.
Tested Application
E, WB
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
SERPINA1 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H, M, R
Protein GI Number
4505793
Protein Accession Number
NP_000286
Molecular Weight
46.7 kDa (calculated)
Short Description
a-1 antitrypsin
This product belongs to the following categories:
References- Mahadeva, R., Dafforn,T. R., Carrell,R. W. and Lomas,D. A. 6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha (1)-antitrypsin-related cirrhosis. J. Biol. Chem. 277 (9), 6771-6774 (2002)
Datasheet 0801-W
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