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Primary Antibodies
RHBDD2 Antibody
Background
The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. Little is known about the role of RHBDD2. Its overexpression in breast carcinoma appears to be an indicator of poor prognosis and may play a role in breast cancer progression. The related proteins RHBDD1 and RHBDD3 are both involved in the regulation of apoptosis, suggesting that RHBDD2 may also be involved in the modulation of apoptotic activity.
Additional Names
RHBDD2, Rhomboid domain containing 2, RHBDL7, NPD007
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Description
Left: Western blot analysis of RHBDD2 in rat lung tissue lysate with RHBDD2 antibody at (A) 1 and (B) 2 μg/ml.
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Source
RHBDD2 antibody was raised against an 18 amino acid peptide from near the center of human RHBDD2.
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
RHBDD2 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application
RHBDD2 antibody can be used for detection of RHBDD2 by Western blot at 1 - 2 μg/ml.
Tested Application
E, WB
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat.No. 5527P - RHBDD2 Peptide
Storage
RHBDD2 antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1462 - Rat Lung Tissue Lysate
Species Reactivity
H, M, R
Protein GI Number
94818790
Protein Accession Number
NP_001035546
Short Description
Rhomboid domain containing 2
This product belongs to the following categories:
References- Koonin EV, Makarova KS, Rogozin IB, et al. The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple horizontal gene transfers. Genome Biol. 2003; 4:R19.
- Abba MC, Sun H, Hawkins KA, et al. Breast cancer molecular signatures as determined by SAGE: correlation with lymph node status. Mol. Cancer Res. 2007; 5:881-90.
- Abba MC, Lacunza E, Nunez MI, et al. Rhomboid domain containing 2 (RHBDD2): a novel cancer-related gene over-expressed in breast cancer. Biochim. Biophys. Acta 2009; 1792:988-97.
- Wang Y, Guan X, Fok KL, et al. A novel member of the rhomboid family, RHBDD1, regulates BIK-mediated apoptosis. Cell Mol. Life Sci. 2008; 65:3822-9.
Datasheet 10-01W
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