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Primary Antibodies
RGPD5 Antibody
Background
The RANBP2-like and GRIP domain containing 5 protein (RGPD5) has high similarity to RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. The gene coding for RGPD5 is thought to have arisen from a gene duplication event of RANBP2 as these highly homologous genes are located close to each other at chromosome 2q11-q12. RGPD5 was identified as an HIV dependency factor (HDF), suggesting that RGPD5 may be an important drug target in HIV treatment. At least two isoforms of RGPD5 are known to exist, of which the shorter isoform is expressed primarily in testis, while the longer of the two is expressed at low levels in a number of somatic tissues.
Additional Names
RGPD5 (NT), RANBP2-like and GRIP domain-containing protein 5, RGP5, RANBP2L1
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Description
Left: Western blot analysis of RGPD5 in human thymus tissue lysate with RGPD5 antibody at 1 μg/ml.
Below: Immunohistochemistry of RGPD5 in human testis tissue cells with RGPD5 antibody at 10 μg/ml.
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Other Product Images
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Source
RGPD5 antibody was raised against a 13 amino acid peptide from near the amino terminus of human RGPD5.
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
RGPD5 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application
RGPD5 antibody can be used for detection of RGPD5 by Western blot at 1 – 2 μg/ml.
Tested Application
E, WB, IHC
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat.No. 4585P - RGPD5 Peptide
Storage
RGPD5 antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1314 - Human Thymus Tissue Lysate
Species Reactivity
H
Protein GI Number
83267877
Protein Accession Number
NP_005045
Short Description
(NT) RANBP2-like and GRIP domain-containing protein 5
This product belongs to the following categories:
Related Products
References- Nothwang HG, Rensing C, Kubler M, et al. Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on chromosome 2q11-q12. Genomics 1998; 47:383-92.
- Brass AL, Dykxhoorn DM, Benita Y, et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science 2008; 319:921-6.
- Wang LF, Zhu HD, Miao SY, et al. Molecular cloning and characterization of a novel testis-specific nucleoporin-related gene. Arch. Androl. 1999; 42:71-84.
Datasheet 09-01W
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