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Primary Antibodies
PLEKHM2 Antibody
Background
PLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a recent study examining differential gene expression in human hematopoietic stem cells has shown it to be specifically expressed in stem cells, suggesting that PLEKHM2 may play a role in erythroid commitment and development. Other studies have shown that PLEKHM2 is required for interaction with the Salmonella virulence factor SifA for Salmonella pathogenesis, suggesting that PLEKHM2 has cellular roles other than in the developing embryo.
Additional Names
PLEKHM2, Pleckstrin homology domain containing family M member 2, SKIP
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Description
Left: Western blot analysis of PLEKHM2 in rat brain tissue lysate with PLEKHM2 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.
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Source
PLEKHM2 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human PLEKHM2.
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
PLEKHM2 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application
PLEKHM2 antibody can be used for detection of PLEKHM2 by Western blot at 0.5 - 1 μg/ml.
Tested Application
E, WB
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat.No. 5485P - PLEKHM2 Peptide
Storage
PLEKHM2 antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1463 - Rat Brain Tissue Lysate
Species Reactivity
H, M, R
Protein GI Number
55666400
Protein Accession Number
CAH72018
Short Description
Pleckstrin homology domain containing family M member 2
This product belongs to the following categories:
References- Liu X-L, Yuan J-Y, Zhang J-W, et al. Differential gene expression in human hematopoietic stem cells specified toward erythroid, megakaryotic, and granulocytic lineage. J. Leuk. Biol. 2007; 82:986-1002.
- Diacovich L, Dumont A, Lafitte D, et al. Interaction between the SifA virulence factor and its host target SKIP is essential for Salmonella pathogenesis. J. Biol. Chem. 2009; 284:33151-60.
Datasheet 10-01W
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