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Primary Antibodies
PGCC1 Antibody
Background
The transcription factor peroxisome proliferator-activated receptor gamma (PPARg) plays essential roles in adipogenesis by regulating adipocyte-specific genes through association of various co-factors. One such co-factor, PGCC1 (also known as FAM120B), is widely expressed in adult tissues and throughout embryonic development. Overexpression of this protein in OP9 pre-adipocytes promoted their differentiation into adipocytes, and knockdown of PGCC1 expression through RNA interference blocked this process. PGCC1 is homologous to C9orf10 (also known as FAM120A) and has been mapped to chromosome Xp11.22. At least two isoforms of PGCC1 are known to exist. This antibody will not cross-react with FAM120A.
Additional Names
PGCC1,Constitutive coactivator of PPAR-gamma 1, CCPG, FAM120B
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Description
Left: Western blot analysis of PGCC1 in rat thymus tissue lysate with PGCC1 antibody at (A) 0.5 and (B) 1 μg/ml.
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Source
PGCC1 antibody was raised against an 18 amino acid peptide from near the carboxy terminus of human PGCC1.
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
PGCC1 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application
PGCC1 antibody can be used for detection of PGCC1 by Western blot at 0.5 - 1 μg/ml.
Tested Application
E, WB
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat.No. 5309P - PGCC1 Peptide
Storage
PGCC1 antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1471 - Rat Thymus Tissue Lysate
Species Reactivity
H, M, R
Protein GI Number
74751843
Protein Accession Number
Q96EK7
Short Description
Constitutive coactivator of PPAR-gamma 1
This product belongs to the following categories:
References- Berger J and Moller DE. The mechanisms of actions of PPARs. Annu. Rev. Med. 2002; 53:409-35.
- Li D, Kang Q, and Wang D-M. Constitutive coactivator of peroxisome proliferator-activated receptor (PPARg), a novel coactivator of PPARg that promotes adipogenesis. Mol. Endocrin. 2007; 21:2320-33.
- Holden S and Raymond FL. The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34. Gene 2003; 318:149-61.
Datasheet 09-01W
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