|
Primary Antibodies
PARK7 Antibody
Background
The product of the PARK7 gene, known as PARK7, Parkinson disease (autosomal recessive, early onset) 7, DJ-1 mutant, and DJ-1 oncogene product, functions as a positive regulator of androgen receptor-dependent transcription. PARK7 may also function as a redox-sensitive chaperone and as a sensor for oxidative stress and also has been reported to prevent aggregation of SNCA. PARK7 protects neurons against oxidative stress and cell death and plays a role in fertilization. While PARK7 has no proteolytic activity, it does have a weak transforming activity. PARK7 forms a homodimer and binds to DJBP and PIAS2. PARK7 is part of a ternary complex containing PARK7, DJBP and AR and shows both a nuclear and cytoplasmic localization. In some cells, PARK7 is associated with mitochondria, particularly after oxidative stress. This protein is highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart tissue, and is expressed at lower levels in placenta and brain. PARK7 is detected in tau inclusions in brains from neurodegenerative disease patients, in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa. Defects in PARK7 are the cause of autosomal recessive early-onset Parkinson's disease 7 (PARK7). Parkinson's disease (PD) is a complex, multifactorial disorder that is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, response to treatment with levodopa, the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins) in surviving neurons.
Additional Names
PARK7, DJ-1, DJ1, FLJ27376, dj-1, dj-1 protein, park-7, park7
|
Description
Left: Immunohistochemistry staining of PARK7 in pancreas (formalin-fixed paraffin-embedded) using PARK7 antibody.
|
Purification
Immunoaffinity Chromatography
Clonality / Clone
This is a polyclonal antibody.
Host
PARK7 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
PARK7 antibody was raised against aa 177-189 of PARK7. (Human)
Application
PARK7 antibody can be used for detection of PARK7 by WB (1:500 - 1:2000), ELISA (1:10000 - 1:50000), IHC-parafin (2.5 μg/ml).
Tested Application
E, WB, IHC
Buffer
PARK7 antibody is supplied in 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
Storage
PARK7 antibody can be stored at -20˚C prior to opening. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20˚C or below. Avoid cycles of freezing and thawing.
Species Reactivity
M, R, C, D, X
Formulation
Weight: 50 μg
Concentration: 1 mg/ml
Short Description
Parkinson Disease 7
This product belongs to the following categories:
Datasheet 09-01W
|
|
