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Primary Antibodies
NOTCH2 Antibody
Background
Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.
Additional Names
NOTCH2, AGS2, HN2, notch group protein (n)
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Description
Left: Immunohistochemistry staining of NOTCH2 in liver (formalin-fixed paraffin-embedded) using NOTCH2 antibody.
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Purification
Sterile Filtration
Clonality / Clone
This is a polyclonal antibody.
Host
NOTCH2 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
NOTCH2 antibody was raised against Amino acid residues near the N-terminal sequence of NOTCH2. (Human)
Application
NOTCH2 antibody can be used for detection of NOTCH2 by ELISA, IHC-parafin (1:500).
Tested Application
E, IHC
Buffer
NOTCH2 antibody is supplied in 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
Storage
NOTCH2 antibody can be stored at 4˚C or -20˚C. Avoid repeated freezing and thawing.
Species Reactivity
H
Formulation
Volume: 50 μl
Short Description
Notch Homolog 2
This product belongs to the following categories:
Datasheet 09-01W
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