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Primary Antibodies
NFKBIB Antibody
Background
NFkB was originally identified as a factor that binds to the immunoglobulin kappa light chain enhancer in B cells. It was subsequently found in non-B cells in an inactive cytoplasmic form consisting of NFkB bound to IkB. NFkB was originally identified as a heterodimeric DNA binding protein complex consisting of p65 (RelA) and p50 (NFKB1) subunits. Other identified subunits include p52 (NFKB2), c-Rel, and RelB. The p65, cRel, and RelB subunits are responsible for transactivation. The p50 and p52 subunits possess DNA binding activity but limited ability to transactivate. p52 has been reported to form transcriptionally active heterodimers with the NFkB subunit p65, similar to p50/p65 heterodimers. The heterodimers of p52/p65 and p50/p65 are regulated by physical inactivation in the cytoplasm by IkB-a. IkB-a binds to the p65 subunit, preventing nuclear localization and DNA binding. Low levels of p52 and p50 homodimers can also exist in cells.
Additional Names
NFKBIB, I-KAPPA-B-BETA, IKAPPABBETA, IKB-B, IKB-BETA, IKBB, NF-KAPPA-BIB, TRIP9, I-kappa-B beta, ikappabbeta, IKB-beta, nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, beta
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Description
Left: Immunohistochemistry staining of NFKBIB in small intestine, peyer's patch (formalin-fixed paraffin-embedded) using NFKBIB antibody.
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Purification
Delipidation and Defibrination
Clonality / Clone
This is a polyclonal antibody.
Host
NFKBIB antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
NFKBIB antibody was raised against the C-terminus regionNFKBIB. (Human)
Application
NFKBIB antibody can be used for detection of NFKBIB by WB, IP, ELISA, IF, IHC-parafin (1:500).
Tested Application
E, WB, IHC, IF, IP
Buffer
NFKBIB antibody can be stored at -20˚C or below prior to opening. Dilute only prior to immediate use. Aliquot contents and freeze at -20˚C or below. Avoid cycles of freezing and thawing.
Species Reactivity
H
Formulation
Volume: 50 μl
Short Description
Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-cells Inhibitor
This product belongs to the following categories:
Datasheet 09-01W
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