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Primary Antibodies
NFKB1 Antibody
Background
Nuclear factor κ-B DNA binding subunit; Nuclear factor of κ light chain gene enhancer in B-cells 1 (p105). NFκB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFκB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-κ-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-κ-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth.
Location
The gene that codes for this protein is at chromosomal location 4q24.
Purification
Antigen affinity-purified
Clonality / Clone
This is a polyclonal antibody.
Host
NFKB1 antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
432-499
Application
NFkB antibody can be used for the detection of NFkB by Western blot, may also work for IHC and ICC.
Tested Application
WB
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
NFKB1 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H, M, R
Protein GI Number
10835177, 189178
Protein Accession Number
NP_003989.1
Molecular Weight
105.4 kDa (calculated)
Short Description
Nuclear factor κ-B DNA binding subunit
This product belongs to the following categories:
References- Anest, V., Hanson, J. L., Cogswell, P. C., Steinbrecher, K. A., Strahl, B. D., Baldwin, A. S. A nucleosomal function for I-kappa-B kinase-alpha in NF-kappa-B-dependent gene expression. Nature 423: 659-663, 2003.
Datasheet 0801-W
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