|
Primary Antibodies
NELFA Antibody
Background
Wolf-Hirschhorn syndrome candidate 2 protein; WHSC2 protein; NELFA. WHSC2 is expressed ubiquitously with higher levels in fetal than in adult tissues. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
Additional Names
WHSC2 (M188)
|
Description
WHSC2 (M-188) IgY Antibody
|
Location
The gene that codes for this protein is at chromosomal location 4p16.3.
Purification
Antigen affinity-purified
Clonality / Clone
This is a polyclonal antibody.
Host
NELFA antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
104-291
Application
NELFA antibody can be used for the detection of WHSC2 (M-188) by Western blot, may also work for IHC and ICC.
Tested Application
WB
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
NELFA antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H, M, R
Protein GI Number
5032227
Protein Accession Number
NP_005654.1
Molecular Weight
57.3 kDa (calculated)
Short Description
Wolf-Hirschhorn syndrome candidate 2 protein
This product belongs to the following categories:
Related Products
References- Narita,T., Yamaguchi,Y., Yano,K., Sugimoto,S., Chanarat,S., Wada,T., Kim,D. K., Hasegawa,J., Omori,M., Inukai,N., Endoh,M., Yamada,T. and Handa,H. Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex. Mol. Cell. Biol. 23 (6), 1863-1873 (2003).
Datasheet 0801-W
|
|
