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Primary Antibodies
MECP2 Antibody
Background
Methyl CpG binding protein 2 (Rett syndrome). DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
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Description
MeCP2 IgY Antibody
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Location
The gene that codes for this protein is at chromosomal location Xq28.
Purification
Antigen affinity-purified
Clonality / Clone
This is a polyclonal antibody.
Host
MECP2 antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
170-486
Application
MeCP2 antibody can be used for the detection of MeCP2 by Western blot, may also work for IHC and ICC.
Tested Application
WB
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
MECP2 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H, M, R
Protein GI Number
4826830
Protein Accession Number
NP_004983.1
Molecular Weight
52.4 kDa (calculated)
This product belongs to the following categories:
References- Nan,X., Campoy,F. J. and Bird,A. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell 88 (4), 471-481 (1997).
Datasheet 0801-W
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