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Primary Antibodies
MAP3K7IP2 Antibody
Background
MAP3K7IP2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of NF&kappa:B and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serving as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF&kappa:B (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Transcript variant (1) encodes the longer isoform (1).
Additional Names
FLJ21885, KIAA0733, TAB2
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Description
Left: Western blot analysis of MAP3K7IP2 in HepG2 cell lysate using anti-MAP3K7IP2.
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Purification
Rabbit IgG is purified by peptide affinity chromatography method.
Clonality / Clone
This is a polyclonal antibody.
Host
MAP3K7IP2 antibody was raised in rabbit.
Please use anti-rabbit IgG secondary antibodies.
Immunogen
MAP3K7IP2 antibody was produced in rabbits immunized with a synthetic peptide corresponding to a region of human MAP3K7IP2.
Application
MAP3K7IP2 antibody can be used for Western blot at a suggested dilution of 0.5-6.0 ug/ml in 5% skim milk / PBS buffer, and HRP conjugated anti Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody. The protein size is 693 amino acids.
Tested Application
WB, IHC
Buffer
Antibody is supplied in PBS buffer with 2% sucrose.
Storage
MAP3K7IP2 antibody is supplied in PBS buffer containing 0.02% sodium azide. For longer periods of storage, store at -20ºC. Avoid repeat freeze-thaw cycle.
Positive Control
- Cat. No. 1211 - HepG2 Cell Lysate
Species Reactivity
H
Protein Accession Number
NP_055908
Molecular Weight
76kDa
This product belongs to the following categories:
Related Products
References- Kanayama, A., et al. (2004) Mol. Cell 15 (4), 535-548
Datasheet 0802-W
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