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Primary Antibodies
LMAN1 Antibody
Background
FUNCTION: Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
DISEASE: Defects in LMAN1 are a cause of factor V and factor VIII combined deficiency (F5F8D) [MIM:227300]; also known as multiple coagulation factor deficiency I (MCFD1). F5F8D is an autosomal recessive bleeding disorder characterized by coordinate reduction of both clotting proteins. Affected patients present with a moderate bleeding tendency and have factor V and factor VIII levels in the range of 5-30% of normal.
Additional Names
ERGIC53 protein, ER-Golgi intermediate compartment 53 kDa protein, Lectin, mannose-binding 1, Gp58, Intracellular mannose-specific lectin MR60
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Description
Left: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
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Location
The gene that codes for this protein is at chromosomal location 18q21.3-q22.
Purification
Immunoaffinity Purified
Clonality / Clone
This is a polyclonal antibody.
Host
LMAN1 antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
270-470
Application
ERGIC-53 protein antibody can be used for the detection of ERGIC-53 protein by Western Blot.
Tested Application
WB
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
LMAN1 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H
Protein GI Number
5031873
Protein Accession Number
NP_005561.1
Molecular Weight
57.5 kDa (calculated)
Short Description
Intracellular mannose-specific lectin MR60
This product belongs to the following categories:
Datasheet 0801-W
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