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Primary Antibodies
LGI2 Antibody
Background
The leucine-rich, glioma inactivated gene 2 (LGI2) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI2 have not been found to be associated with ADTLE. Three isoforms of LGI2 are known to exist; this LGI2 antibody will recognize only the longest. This LGI2 antibody is predicted to be specific to LGI2 and not recognize other LGI proteins.
Additional Names
LGI2 (NT), Leucine-rich, glioma inactivated 2, LGIL2
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Description
Left: Western blot analysis of LGI2 in 293 cell lysate with LGI2 antibody at (A) 1 and (B) 2 μg/ml.
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Source
LGI2 antibody was raised against an 11 amino acid peptide from near the amino terminus of human LGI2.
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
LGI2 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application
LGI2 antibody can be used for the detection of LGI2 by Western blot at 1 – 2 μg/ml.
Tested Application
E, WB
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat.No. 4491P - LGI2 Peptide
Storage
LGI2 antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1210 - 293 Cell Lysate
Species Reactivity
H, M, R
Protein GI Number
32469737
Protein Accession Number
Q8K4Z0
Short Description
(NT) Leucine-rich, glioma inactivated 2
This product belongs to the following categories:
Related Products
References- Gu W, Gibert Y, Wirth T, et al. Using gene-history and expression analysis to assess the involvement of LGI genes in human disorders. Mol. Biol. Evol. 2005; 22:2209-16.
- Chernova OB, Somerville RP and Cowell JK. A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors. Oncogene 1998; 17:2873-81.
- Berkovic SF, Izzillo P, McMahon JM, et al. LGI1 mutations in temporal lobe epilepsies. Neurology 2004; 62:1115-9.
Datasheet 08-02W
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