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Primary Antibodies
LASS6 Antibody
Background
The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. Like the highly homologous LASS5, LASS6 is also an endoplasmic reticulum, multi-pass membrane protein. LASS6 is also involved in the synthesis of C14, C16 and C18-ceramide, but shows a preference for unsaturated fatty acids. LASS6 is broadly expressed in a wide range of tissues and microarray data suggests that it may play a role in cancer differentiation and early embryonic development. At least two isoforms of LASS6 are known to exist. This antibody is predicted not to cross-react with LASS5.
Additional Names
LASS6, Longevity Assurance Homolog 6, LAG1 homolog 6
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Description
Left: Western blot analysis of LASS6 in rat brain tissue lysate with LASS6 antibody at (A) 1 and (B) 2 μg/ml.
Below: Immunohistochemistry of LASS6 in mouse brain tissue with LASS6 antibody at 2.5 μg/ml.
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Other Product Images
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Source
LASS6 antibody was raised against a 13 amino acid peptide near the amino terminus of the human LASS6.
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
LASS6 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application
LASS6 antibody can be used for detection of LASS6 by Western blot at 1 – 2 μg/ml.
Tested Application
E, WB, IHC
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat.No. 4941P - LASS6 Peptide
Storage
LASS6 antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1463 - Rat Brain Tissue Lysate
Species Reactivity
H, M, R
Protein GI Number
80478334
Protein Accession Number
AAI09285
Short Description
longetivity, sphingolipids, ceramide synthesis
This product belongs to the following categories:
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References- Riebeling C, Allegood JC, Wang E, et al. Two mammalian longevity assurance gene (LAG1) family members, Trh1 and Trh, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J. Biol. Chem. 2003; 278:43452-9.
- Mizutani Y, Kihara A and Igarashi Y. Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem. J. 2005; 390:263-71.
- Lahiri S and Futerman AH. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. J. Biol Chem. 2005; 280:33735-8.
- Weinmann A, Galle PR, and Teufel A. LASS6, an additional member of the longevity assurance gene family. Int. J. Mol. Med. 2005; 16:905-10.
Datasheet 09-01W
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