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Primary Antibodies
IL-21 Receptor Antibody
Background
A novel cytokine related to IL-2 and IL-15 was recently identified and designated IL-21 . The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1,2). IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling (3,4). Both IL-21R and the gc are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
Additional Names
IL-21 Receptor (ED), IL21R
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Description
Left: Western blot analysis of IL-21 receptor expression in human Raji cell lysate with IL-21 Receptor antibody at 1 μg /ml.
Below: Immunohistochemistry of IL-21 receptor in rat lung with IL-21 receptor antibody at 10 μg/ml.
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Other Product Images
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Source
IL-21 receptor antibody was raised against a synthetic peptide corresponding to amino acids 97 to 111 of human IL-21 receptor precursor .
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
IL-21 Receptor antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
Human IL-21 Receptor (Extracellular Domain) Peptide (Cat. No. 2469P)
Application
IL-21 receptor antibody can be used for detection of IL-21 receptor by Western blot at 0.5 to 1 μg/ml. An approximately 60 kDa band can be detected.
Tested Application
E, WB, IHC
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat. No. 2469P - IL-21 Receptor Peptide
Storage
IL-21 Receptor antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1207 - Raji Cell Lysate
- Cat. No. 1462 - Rat Lung Tissue Lysate
Species Reactivity
H, M, R
Protein GI Number
11141869
Protein Accession Number
NP_068570
Short Description
(ED) Interleukin 21 receptor
This product belongs to the following categories:
Related Products
References- Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000;408(6808):57-63.
- Ozaki K, Kikly K, Michalovich D, et al. Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain. Proc Natl Acad Sci USA . 2000;97(21):11439-44.
- Asao H, Okuyama C, Kumaki S, et al. the common γ-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 2001;167(1):1-5.
- Vosshenrich CA, Di Santo JP. Cytokines: IL-21 joins the γ(c)-dependent network.Curr Biol. 2001;11(5):R175-7.
Datasheet 08-02W
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