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| Ar | Arabidopsis |
| B | Bovine |
| BA | Baboon |
| Bc | Bacteria |
| Bl | Blocking |
| Bt | Biotinylated |
| Ce | C. elegans |
| C | Chicken |
| Chm | Chimpanzee |
| CP | Carp |
| CT | C-Terminus |
| D | Dog |
| Ds | Drosophila |
| E | ELISA |
| ED | Extracellular Domain |
| EL | Extracellular Loop |
| F | Feline |
| FACS | Flow Cytometry |
| Fu | Fungus |
| G | Guinea Pig |
| Gt | Goat |
| H | Human |
| HM | Hamster |
| Hr | Horse |
| I | Immunogen |
| ICC | Immunocytochemistry |
| ID | Intracellular Domain |
| IF | Immunofluorescence |
| IHC | Immunohistochemistry |
| IN | Intermediate Domain |
| IP | Immunoprecipitation |
| M | Mouse |
| Ma | Mammal |
| Mk | Monkey |
| MS | Mass Spectrometry |
| Mt | M. tuberculosis |
| N | Neutralization |
| NT | N-Terminus |
| P | Porcine |
| Pa | Parasite |
| PF | Puffer Fish |
| Pl | Plant |
| Pz | Protozoan |
| R | Rat |
| Rb | Rabbit |
| S | Sheep |
| V | Virus |
| WB | Western Blot |
| X | Xenopus |
| Y | Yeast |
| ZF | Zebra Fish |
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Products
Primary Antibodies
Neurobiology Antibodies: Huntington's Disease Antibodies
Huntington’s disease is a genetically inherited degenerative disease which causes cell death via apoptosis in selective areas of the brain. Huntington’s disease causes loss of motor control, mental deterioration and emotional disturbances. It is classified as a polyglutamine disease because of a high number of CAG repeats, which code for glutamine, in the huntingtin gene.
Caspase-8, is an initiator caspase, and has been shown to play an important role in Huntington’s disease. Caspase-8 is activated by proteolysis in association with the expression of polyglutamine in the huntingtin gene which is associated with Huntington’s disease. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been implicated in a number of neurodegenerative diseases because it has been found to bind to the β-amyloid precursor protein and the mutated polyglutamine present in Huntington’s disease. Also, the papillomavirus regulatory factor-1 (PRF-1) is a transcription factor which binds to a consensus sequences of GCCGGCG, which is an essential cis-element for Huntington’s disease gene expression in human neuronal cells.
ProSci has many Huntington’s disease antibodies, including antibodies to the proteins mentioned here. ProSci’s Huntington’s disease antibodies include antibodies against Caspase-8, Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and papillomavirus regulatory factor-1 (PRF-1). ProSci antibodies are appropriate for ELISA, western blot, and immunohistochemistry (IHC) applications as noted for each Huntington’s disease antibody.
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| BDNF Antibody |
XP-5108 |
H |
E, WB |
Anti-Human BDNF - Rabbit |
| BDNF Antibody |
XP-5108Bt |
H |
E, WB |
Biotin - Anti-Human BDNF - Rabbit |
| Calbindin Antibody |
48-445 |
M, R |
WB, IHC |
Calbindin |
| CASP8 Antibody |
XW-7072 |
H |
WB |
MACH-a-1 |
| Caspase-8 Antibody |
3473 |
H, M, R |
E, WB, ICC |
(CT) an initiator caspase |
| Caspase-8 Antibody |
3475 |
H, M |
E, WB |
(E) an initiator caspase |
| GAPDH Antibody |
3781 |
H, M, R |
E, WB, IHC |
(CT) an enzyme in the glycolytic pathway |
| GAPDH Antibody |
3783 |
H, M, R |
E, WB, IHC |
(NT) An eznyme in the glycolytic pathway |
| HAP1 Antibody |
4205 |
H, M, R |
E, WB, IHC |
Huntingtin associated protein 1 |
| KALRN Antibody |
46-975 |
H, M, R, B, Hr |
E |
(NT) KALRN |
| Prion Protein Antibody (PrPsc) |
35-593 |
Bc |
E, WB, IHC |
Reactive with the protease resistant form of PrP in sheep and cattle. |
| QPRT Antibody |
XW-8023 |
H |
WB |
Nicotinate-nucleotide pyrophosphorylase (Carboxylating) |
| ZNF395 Antibody |
XW-7461 |
H, M, R |
WB |
Papillomavirus regulatory factor PRF-1 |
| ZNF395 Antibody |
XW-7462 |
H, M, R |
WB |
Papillomavirus regulatory factor PRF-1 |
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