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Primary Antibodies
Grik3 Antibody
Background
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik3, also known as glutamate receptor 7, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik3 is highly homologous to the related ionotrophic glutamate receptors Grik2 and Grik1. Grik3 has recently been shown to be an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses as grik3-null mice show significantly reduced short- and long-term synaptic potentiation. Other reports have suggested that different polymorphisms in the Grik3 protein may be associated with neurological defects such as recurrent major depressive disorder and schizophrenia. This Grik3 antibody does not cross-react with Grik2.
Additional Names
Grik3, Glutamate receptor ionotropic kainate 3, glutamate receptor 7, gluR7, excitatory amino acid receptor 5, eea5
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Description
Left: Western blot analysis of Grik3 in human brain tissue lysate with Grik3 antibody at (A) 1 and (B) 2 μg/ml.
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Source
Grik3 antibody was raised against a 13 amino acid peptide near the amino terminus of the human Grik3.
Clonality / Clone
This is a polyclonal antibody.
Host
Grik3 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application
Grik3 antibody can be used for detection of Grik3 by Western blot at 1 – 2 μg/ml.
Tested Application
WB
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Storage
Grik3 antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1303 - Human Brain Tissue Lysate
Species Reactivity
H,M,R
Protein Accession Number
NP_000822
Data Sheet Version
08-02W
Related Products
References
- Tanaka K. Functions of glutamate transports in the brain. Neurosci. Res. 2000; 37:15-9.
- Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res. 2006; 326:457-82.
- Puranam RS, Eubanks JH, Heinemann SF, et al. Chromosomal localization of gene for human glutamate receptor subunit-7. Somat. Cell Mol. Genet. 1993; 19:581-8.
- Pinheiro PS, Perrais D, Coussen F, et al. GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses. Proc. Natl. Acad. Sci. USA 2007; 104:12181-6.
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