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Primary Antibodies
GABRG2 Antibody
Background
Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA (A) subunits. GABRG2 is the gamma 2 subunit of GABA (A) receptor. Mutations in this gene have been associated with epilepsy and febrile seizures.Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA (A) subunits. This gene encodes the gamma 2 subunit of GABA (A) receptor. Mutations in this gene have been associated with epilepsy and febrile seizures. Alternative splicing of this gene results in transcript variants encoding different isoforms.
Additional Names
GABRG2, CAE2, ECA2, GEFSP3
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Description
Left: Western blot analysis of GABRG2 in HepG2 Cell Lysate using GABRG2 antibody at 1.25 μg/ml (12% gel).
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Purification
Antibody is purified by protein A chromatography method.
Clonality / Clone
This is a polyclonal antibody.
Host
GABRG2 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GABRG2.
Application
GABRG2 antibody can be used for detection of GABRG2 by ELISA at 1:62500. GABRG2 antibody can be used for detection of GABRG2 by western blot at 1.25 μg/ml, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Tested Application
E, WB
Buffer
Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μl of distilled water. Final antibody concentration is 1 mg/ml.
Storage
For longer periods of storage, store GABRG2 antibody at -20˚C. Avoid repeat freeze-thaw cycles.
Species Reactivity
H, M, R, D
Protein Accession Number
NP_944493
Molecular Weight
36kDa, 54kDa, 55kDa
Short Description
GABRG2 (gamma-aminobutyric acid (GABA) A receptor, gamma 2)
This product belongs to the following categories:
References- Sancar,F. (2004) J. Biol. Chem. 279 (45), 47034-47039.
Datasheet 10-01W
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