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Primary Antibodies
FABP7 Antibody
Background
FABP7 was initially isolated from a human fetal brain cDNA library and whose mRNA was expressed in adult brain and muscle tissues at low levels. The protein encoded by this gene is a member of the fatty acid binding protein (FABPs) family, a group of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism. FABP7 is a downstream gene of the Pax6 transcription factor and has been suggested to be essential for the maintenance of neuroepithelial cells during early cortical development. More recently, FABP7 was found to be frequently expressed in melanomas. Down-regulation of FABP7 through RNAi expression could reduce in vitro cell proliferation and Matrigel invasion, suggesting that FABP7 may be a potential target for the development of diagnostic and therapeutic tools.
Additional Names
FABP7 (IN), Fatty acid binding protein 7, B-FABP, MRG, BLBP
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Description
Left: Western blot analysis of FABP7 in human breast tissue lysate with FABP7 antibody at (A) 0.5, (B) 1 and (C) 2 μg/ml.
Below: Immunohistochemistry of FABP7 in human breast tissue with FABP7 antibody at 5 μg/ml.
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Other Product Images
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Source
FABP7 antibody was raised against a 17 amino acid peptide from near the center of human FABP7.
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
FABP7 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application
FABP7 antibody can be used for detection of FABP7 by Western blot at 0.5 – 1 μg/ml.
Tested Application
E, WB, IHC
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat.No. 4259P - FABP7 Peptide
Storage
FABP7 antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1311 - Human Breast Tissue Lysate
Species Reactivity
H
Protein GI Number
119568551
Protein Accession Number
EAW48166
Short Description
(IN) Fatty acid binding protein 7
This product belongs to the following categories:
Related Products
References- Shimizu F, Watanabe TK, Shinomiya H, et al. Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP). Biochim. Biophys. Acta 1997; 1354:24-8.
- Chmurzynska A. The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism. J. Appl. Genet. 2006; 47:39-48.
- Arai Y, Funatsu N, Numayama-Tsuruta K, et al. Role of FABP7, a downstream gene of pax6, in the maintenance of neuroepithelial cells during early embryonic development of the rat cortex. J. Neurosci. 2005; 25:9752-61.
- Goto Y, Matsuzaki Y, Kurihara S, et al. A new melanoma antigen fatty acid-binding protein 7, involved in proliferation and invasion, is a potential target for immunotherapy and molecular target therapy. Cancer Res. 2006; 66:4443-9.
Datasheet 08-03W
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