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Primary Antibodies
ELOVL6 Antibody
Background
Lipogenesis is a key event in the energy storage system and is controlled by the transcription factor sterol regulatory element-binding protein (SREBP)-1. Elongation of very long chain fatty acids protein 6 (ELOVL6) is a member of fatty acyl-CoA elongase gene family that converts palmitic to stearic acid and it has been shown to be a target of SREBP-1, playing an important role in de novo synthesis of long-chain saturated and monosaturated fatty acids in conjunction with fatty acid synthase and stearoyl-CoA desaturase ELOVL6 was predicted to be important for tissue fatty acid composition. Recent studies suggest that inhibition of this elongase could be a new therapeutic approach for ameliorating insulin resistance, diabetes and cardiovascular risks, even in the presence of a continuing state of obesity.
Additional Names
ELOVL6, Elongation of very long chain fatty acids protein 6, hELO2, Fatty acyl-CoA elongase, FACE, Long-chain fatty-acyl elongase, LCE
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Description
Left: Western blot analysis of ELOVL6 in Human brain tissue lysate with ELOVL6 antibody at (A) 1 and (B) 2 μg/ml.
Below: Immunohistochemistry of ELOVL6 in human brain with ELOVL6 antibody at 5 μg/ml.
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Other Product Images
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Source
ELOVL6 antibody was raised against a 16 amino acid peptide near the amino terminus of the human ELOVL6.
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
ELOVL6 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application
ELOVL6 antibody can be used for detection of ELOVL6 by Western blot at 1 – 2 μg/ml.
Tested Application
E, WB, IHC
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat.No. 4571P - ELOVL6 Peptide
Storage
ELOVL6 antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1303 - Human Brain Tissue Lysate
Species Reactivity
H, M, R
Protein GI Number
13129088
Protein Accession Number
NP_076995
Short Description
Elongation of very long chain fatty acids protein 6
This product belongs to the following categories:
Related Products
References- Moon YA, Shah NA, Mohapatra S, et al. Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins. J. Biol. Chem. 2001; 276:45358-66.
- Matsuzaka T, Shimano H, Yahaqi N, et al. Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs. J. Lipid Res. 2002; 43:911-20.
- Matsuzaka T, Shimano H, Yahaqi N, et al. Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. Nat. Med. 2007; 13: 1193 -202.
Datasheet 08-03W
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