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| Ar | Arabidopsis |
| B | Bovine |
| BA | Baboon |
| Bc | Bacteria |
| Bl | Blocking |
| Bt | Biotinylated |
| Ce | C. elegans |
| C | Chicken |
| Chm | Chimpanzee |
| CP | Carp |
| CT | C-Terminus |
| D | Dog |
| Ds | Drosophila |
| E | ELISA |
| ED | Extracellular Domain |
| EL | Extracellular Loop |
| F | Feline |
| FACS | Flow Cytometry |
| Fu | Fungus |
| G | Guinea Pig |
| Gt | Goat |
| H | Human |
| HM | Hamster |
| Hr | Horse |
| I | Immunogen |
| ICC | Immunocytochemistry |
| ID | Intracellular Domain |
| IF | Immunofluorescence |
| IHC | Immunohistochemistry |
| IN | Intermediate Domain |
| IP | Immunoprecipitation |
| M | Mouse |
| Ma | Mammal |
| Mk | Monkey |
| MS | Mass Spectrometry |
| Mt | M. tuberculosis |
| N | Neutralization |
| NT | N-Terminus |
| P | Porcine |
| Pa | Parasite |
| PF | Puffer Fish |
| Pl | Plant |
| Pz | Protozoan |
| R | Rat |
| Rb | Rabbit |
| S | Sheep |
| V | Virus |
| WB | Western Blot |
| X | Xenopus |
| Y | Yeast |
| ZF | Zebra Fish |
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Products
Primary Antibodies
Neurobiology Antibodies: Down's Syndrome Antibodies
Down’s syndrome is a chromosomal abnormality characterized by the presence of an extra copy of genetic material on the 21st chromosome, either in whole (trisomy 21) or part (such as due to translocations). The effects of the extra copy vary greatly from individual to individual, depending on the extent of the extra copy, genetic background, environmental factors, and random chance. Down’s syndrome occurs in all human populations, and analogous effects have been found in other species such as chimpanzees and mice. Recently, researchers have been able to create transgenic mice with most of human chromosome 21 (in addition to the normal mouse chromosomes). People with Down's syndrome often have a simian crease on the palmar surface of the hand.
Accumulation of the amyloid-beta (Aβ) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. Amyloid-beta peptide is generated by proteolytic cleavage of the amyloid-beta protein precursor (APP) at β- and γ-sites by proteases. The long-sought β-secretase was recently identified by several groups independently and designated β-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at β-site and at a different site within amyloid-beta. BACE2 locates on chromosome 21q22.3, the so-called Down’s critical region, suggesting that BACE2 and amyloid-beta may also contribute to the pathogenesis of Down’s syndrome.
ProSci has Down’s syndrome antibodies, including antibodies against beta-site APP cleaving enzyme (BACE and BACE2). ProSci antibodies are appropriate for ELISA, western blot, and immunohistochemistry (IHC) applications as noted for each Down’s syndrome antibody.
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