|
Primary Antibodies
DR6 Antibody
Background
Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6 (1). Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.
Additional Names
DR6
|
Description
Left: Western blot analysis of DR6 in K562 (1,3) and Raji (2,4) whole cell lysate in the absence (1,2) or presence (3,4) of blocking peptide (Catalog no. 2157P) with DR6 antibody at 1:500 dilution.
|
Source
DR6 antibody was raised against a peptide corresponding to amino acids 42 to 56 of human DR6 precursor .
Purification
Antibody is DEAE purified
Clonality / Clone
This is a polyclonal antibody.
Host
DR6 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
Murine DR6 (N-Terminus) Peptide (Cat. No. 2157P)
Application
DR6 antibody can be used for detection of DR6 by Western blot at 1:500 to 1:2000 dilution. An approximately 68 kDa band can be detected.
Tested Application
E, WB
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat. No. 2157P - DR6 Peptide
Storage
DR6 antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1201 - HeLa Cell Lysate
- Cat. No. 1204 - K562 Cell Lysate
Species Reactivity
H
Protein GI Number
3549262
Protein Accession Number
AF068868
Short Description
Cell Death Receptor 6
This product belongs to the following categories:
Related Products
References- Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett 1998;431:351-6
Datasheet 08-02W
|
|
