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Primary Antibodies
DDC Antibody
Background
FUNCTION: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
DISEASE: Defects in DDC are the cause of AADC deficiency [MIM:608643]. AADC deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.
Additional Names
AromaticLaminoacid decarboxylase, AADC, DOPA decarboxylase, DDC
Location
The gene that codes for this protein is at chromosomal location 7p11.
Purification
Immunoaffinity Purified
Clonality / Clone
This is a polyclonal antibody.
Host
DDC antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
310-399
Application
Aromatic-L-amino-acid decarboxylase antibody can be used for the detection of Aromatic-L-amino-acid decarboxylase by Western Blot.
Tested Application
WB
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
DDC antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H
Protein GI Number
4503281
Protein Accession Number
NP_000781.1
Molecular Weight
53.9 kDa (calculated)
Short Description
Aromatic-L-amino-acid decarboxylase
This product belongs to the following categories:
Related Products
Datasheet 0801-W
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