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Primary Antibodies
Cyclin A1 Antibody
Background
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
Additional Names
CCNA1, CYCLIN-A1, cyclin a1
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Description
Left: Immunohistochemistry staining of Cyclin A1 in testis (formalin-fixed paraffin-embedded) using Cyclin A1 antibody.
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Purification
Delipidation and Defibrination
Clonality / Clone
This is a polyclonal antibody.
Host
Cyclin A1 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
Cyclin A1 antibody was raised against a full length synthetic peptide corresponding to CCNA1. (Human)
Application
Cyclin A1 antibody can be used for detection of Cyclin A1 by WB, IP, ELISA, IF, IHC-parafin (1:500).
Tested Application
E, WB, IHC, IF, IP
Buffer
Cyclin A1 antibody is supplied in 0.01% sodium azide.
Storage
Cyclin A1 antibody can be stored at 4˚C or -20˚C. Avoid repeated freezing and thawing.
Species Reactivity
H
Formulation
Volume: 50 μl
Concentration: 85 mg/ml
Short Description
Cyclin A1
This product belongs to the following categories:
Datasheet 09-01W
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