|
Primary Antibodies
CXCR4 Antibody
Background
FUNCTION: Receptor for the C-X-C chemokine SDF-1. Transduces a signal by increasing the intracellular calcium ions level. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodelling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a primary receptor for some HIV-2 isolates and as a coreceptor with CD4 for HIV-1 X4 viruses (lymphocyte-tropic HIV-1 viruses, also called syncytium-inducing (SI) strains). Promotes Env-mediated fusion of the virus.
Additional Names
CXC chemokine receptor type 4, CXC-R4, CXCR-4, Stromal cell-derived factor 1 receptor, SDF-1 receptor, Fusin, Leukocyte-derived seven transmembrane domain receptor, LESTR, LCR1, FB22, NPYRL, HM89, CD184 antigen
|
Description
Left: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
|
Location
The gene that codes for this protein is at chromosomal location 2q21.
Purification
Immunoaffinity Purified
Clonality / Clone
This is a polyclonal antibody.
Host
CXCR4 antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
6-41
Application
C-X-C chemokine receptor type 4 antibody can be used for the detection of C-X-C chemokine receptor type 4 by Western Blot.
Tested Application
WB
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
CXCR4 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H, M, R, B
Protein GI Number
4503175
Protein Accession Number
NP_003458.1
Molecular Weight
39.7 kDa (calculated)
Short Description
Leukocyte-derived seven transmembrane domain receptor
This product belongs to the following categories:
Related Products
Datasheet 0801-W
|
|
