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Primary Antibodies
CMKLR1 Monoclonal Antibody
Background
Recognises human serpentine chemokine-like receptor 1 (CMKLR1), a novel chemoattractant receptor, which is also referred to Chem23 or DEZ. CMKLR1 is expressed on plasmacytoid dendritic cells (pDC) in blood but is not expressed on myeloid dendritic cells, lymphocytes, monocytes or granulocytes. Studies show that CMKLR1 is also expressed on dendritic cells, which have been generated in vitro from monocytes. The sole ligand for CMKLR1 is chemerin, a chemoattractant that exists at the mRNA level in a wide range of tissues, and as an inactive proform in serum and plasma. Studies suggest that chemerin, in plasma, is converted into a potent pDC attractant following blood coagulation and may be a process by which pDCG??s are recruited to sites of bleeding and tissue damage.
Additional Names
CMKLR1, chemokine-like receptor 1, chemr23, cmklr1, g protein-coupled receptor dez, gpcr27
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Description
Left: Immunohistochemistry staining of CMKLR1 in placenta (formalin-fixed paraffin-embedded) using CMKLR1 monoclonal antibody.
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Purification
Protein G Column
Clonality / Clone
This is a monoclonal antibody. Clone BZ332.
Isotype
IgG2a
Host
CMKLR1 monoclonal antibody was raised in rat.
Please use anti-rat secondary antibodies.
Immunogen
CMKLR1 monoclonal antibody was raised against a synthetic peptide corresponding to an epitope within the N-terminal region of human CMKLR1. (Human)
Application
CMKLR1 monoclonal antibody can be used for detection of CMKLR1 by Flo (1:25 - 1:100), IHC-parafin (10 μg/ml).
Tested Application
IHC, FACS
Buffer
CMKLR1 monoclonal antibody is supplied in PBS, pH 7.4, 0.09% sodium azide.
Storage
CMKLR1 monoclonal antibody can be stored at 4˚C or -20˚C. Avoid repeated freezing and thawing.
Species Reactivity
n/a
Formulation
Weight: 50 μg
Short Description
Chemokine-like Receptor 1
This product belongs to the following categories:
Datasheet 09-01W
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