|
Primary Antibodies
CDKN1A Antibody
Background
Cyclin-dependent kinase inhibitor 1A; melanoma differentiation associated protein 6; CDK-interaction protein 1; wild-type p53-activated fragment 1; DNA synthesis inhibitor [Homo sapiens]. This protein is a potent cyclin-dependent kinase inhibitor. It binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of p21 gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation.
Additional Names
p21
|
Description
p21 IgY Antibody
|
Location
The gene that codes for this protein is at chromosomal location 6p21.2.
Purification
Antigen affinity-purified
Clonality / Clone
This is a polyclonal antibody.
Host
CDKN1A antibody was raised in chicken.
Please use anti-chicken secondary antibodies.
Immunogen
20-149
Application
p21 antibody can be used for the detection of p21 by Western blot, may also work for IHC and ICC.
Tested Application
WB
Buffer
Phosphate-Buffered Saline. No preservatives added.
Storage
CDKN1A antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Species Reactivity
H, M, R
Protein GI Number
11386203
Protein Accession Number
NP_000380.1
Molecular Weight
18 kDa (calculated)
Short Description
Wild type p53 activated fragment-1 (p21)
This product belongs to the following categories:
Datasheet 0801-W
|
|
