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Primary Antibodies
CDIP Antibody
Background
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.
Additional Names
CDIP (IN1), Cell death involved p53-target
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Description
Left: Western blot analysis of CDIP in human brain lysate with CDIP antibody at (A) 1 and (B) 2 μg/ml.
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Source
CDIP antibody was raised against a 16 amino acid peptide near the center of human CDIP.
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
CDIP antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application
CDIP antibody can be used for detection of CDIP by Western blot at 1 – 2 μg/ml.
Tested Application
E, WB
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat.No. 5047P - CDIP Peptide
Storage
CDIP antibody can be stored at 4˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1303 - Human Brain Tissue Lysate
Species Reactivity
H, M
Protein GI Number
118344450
Protein Accession Number
NP_037531
Short Description
(IN1) Cell death involved p53-target
This product belongs to the following categories:
Related Products
References- Guimaraes DP and Hainaut P. TP53: a key gene in human cancer. Biochimie 2002; 84:83-93.
- Brown L, Ongusaha PP, Kim H-H, et al. CDIP, a novel pro-apoptotic gene, regulates TNFa-mediated apoptosis in a p53-dependent manner. EMBO J. 2007; 26:3410-22.
Datasheet 09-01W
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